Taylor et al. (2010) - Integrative Genomic Profiling of Human Prostate Cancer
Taylor et al. concordantly assessed DNA copy number, exon expression and miRNA expression in 218 prostate cancer tumors. They identified the nuclear receptor coactivator NCOA2 as an oncogene in 11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors.
Copy number tracks